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Maria I Kontaridis Selected Research

LEOPARD Syndrome (Syndrome, LEOPARD)

1/2018Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
1/2017In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy.
1/2016Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.
4/2015Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: palliative treatment with a rapamycin analog.
5/2011PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?
3/2011Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.
5/2010Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.

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Maria I Kontaridis Research Topics

Disease

7LEOPARD Syndrome (Syndrome, LEOPARD)
01/2018 - 05/2010
6Noonan Syndrome (Female Pseudo-Turner Syndrome)
01/2019 - 03/2006
4Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
01/2019 - 03/2011
3Heart Diseases (Heart Disease)
06/2021 - 01/2015
3Neoplasms (Cancer)
01/2017 - 02/2004
3Hypertrophy
01/2017 - 07/2005
2Inborn Genetic Diseases (Disease, Hereditary)
01/2022 - 01/2020
2Ischemia
10/2016 - 11/2012
2Cardiomegaly (Heart Hypertrophy)
04/2015 - 10/2014
2Fibrosis (Cirrhosis)
10/2014 - 11/2012
1Porcine Reproductive and Respiratory Syndrome (PRRS)
06/2021
1Congenital Heart Defects (Congenital Heart Defect)
02/2018
1Hydrocephalus (Hydrocephaly)
01/2018
1Proteus Syndrome
01/2017
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2017
1Infections
10/2016
1Multiple Myeloma
02/2016
1Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
01/2016
1Reperfusion Injury
10/2014
1Heart Failure
10/2014
1Acquired Immunodeficiency Syndrome (AIDS)
11/2012
1Myocardial Infarction
11/2012
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
03/2008
1Cardiovascular Diseases (Cardiovascular Disease)
07/2005
1Hypersensitivity (Allergy)
05/2004

Drug/Important Bio-Agent (IBA)

6Protein Tyrosine PhosphatasesIBA
01/2018 - 02/2004
3Mitogen-Activated Protein KinasesIBA
01/2022 - 03/2008
2Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA
01/2018 - 05/2010
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2016 - 05/2010
2Sirolimus (Rapamycin)FDA Link
04/2015 - 03/2011
1Toll-Like Receptors (Toll-Like Receptor)IBA
06/2021
1Pattern Recognition ReceptorsIBA
06/2021
1Phosphotransferases (Kinase)IBA
01/2019
1MAP Kinase Kinase 1IBA
01/2019
1Tyrosine (L-Tyrosine)FDA Link
01/2018
1MiransertibIBA
01/2017
1Aligeron (AS 2)IBA
01/2017
1LipopolysaccharidesIBA
10/2016
1Metformin (Glucophage)FDA LinkGeneric
10/2016
1Proteins (Proteins, Gene)FDA Link
02/2016
1Brain Natriuretic Peptide (Natrecor)FDA Link
04/2015
1myocardinIBA
10/2014
1Transcription Factors (Transcription Factor)IBA
10/2014
1GuanosineIBA
10/2014
1Serum Response FactorIBA
10/2014
1TAC AlternateIBA
10/2014
1Adenosine Triphosphate (ATP)IBA
11/2012
1Discs Large Homolog 1 ProteinIBA
11/2012
1MitogensIBA
05/2011
1Protein Kinases (Protein Kinase)IBA
05/2011
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
05/2011
1Messenger RNA (mRNA)IBA
05/2010
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
03/2008
1Angiotensin IIIBA
07/2005
1StilbenesIBA
07/2005
1ResveratrolIBA
07/2005
1Caspase 3 (Caspase-3)IBA
05/2004
1Etoposide (VP 16)FDA LinkGeneric
05/2004
1IntegrinsIBA
02/2004
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
02/2004

Therapy/Procedure

3Therapeutics
02/2018 - 01/2015
1Palliative Care (Palliative Therapy)
04/2015